Also Known As: Mirtazapine, Remeron, Avanza, Zispin, Miro
Mirtazapine (Remeron, Avanza, Zispin, Miro) is a tetracyclic antidepressant (TeCA) used primarily in the treatment of depression. It is also sometimes used as a hypnotic, antiemetic, and appetite stimulant, and for the treatment of anxiety, among other indications. Along with its close analogues mianserin and setiptiline, mirtazapine is one of the few noradrenergic and specific serotonergic antidepressants (NaSSAs).
Esmirtazapine, the (S)-(+)-enantiomer of mirtazapine, is currently under development for the treatment of insomnia and menopausal symptoms by the same company that produced mirtazapine.
Mirtazapine's primary use is the treatment of major depressive disorder and other mood disorders.
However, it has also been found useful in alleviating the following conditions and may be prescribed off-label for their treatment:
- Generalized anxiety disorder
- Social anxiety disorder
- Obsessive-compulsive disorder
- Panic disorder
- Post-traumatic stress disorder
- Anorexia nervosa
- Low appetite/underweightness
- Headaches and migraine
Mirtazapine has had a solid amount of literature published on its efficacy (or in some cases lack thereof) in the experimental treatment the following conditions:
- Sleep apnea/hypopnea
- Inappropriate sexual behavior and other secondary symptoms of autistic spectrum conditions and other pervasive developmental disorders
- Neuroleptic-induced akathisia
- Drug withdrawal, dependence, and detoxification