Also Known As: Remdesivir, Veklury

Remdesivir, sold under the brand name Veklury,[1] is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences.[2] It is administered via injection into a vein.[3][4] As of 2020, remdesivir is being tested as a specific treatment for COVID-19, and has been authorized for emergency use in the US, India,[5] Singapore,[6] and approved for use in Japan for people with severe symptoms.[1][7][8][1][9] It also received approval in the UK in May 2020, however, it was going to be rationed due to limited supply.[10] It may shorten the time it takes to recover from the infection.[11]

The most common side effect in healthy volunteers is raised blood levels of liver enzymes (a sign of liver problems).[12] The most common side effects in people with COVID-19 is nausea (feeling sick).[12]

Side effects may include liver inflammation and an infusion-related reaction with nausea, low blood pressure, and sweating.[13] It is a prodrug that is intentended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase [14][15].

Earlier studies found antiviral activity against several RNA viruses including SARS coronavirus and MERS coronavirus, but it is not approved for any indication.[2][7] Remdesivir was originally developed to treat hepatitis C[16] and was then tested against Ebola virus disease and Marburg virus disease, but was ineffective for all of these viral infections.[2]

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