Also Known As: Enalapril, Vasotec, Enaladex
Enalapril (marketed as Vasotec in the USA and Enaladex in some other countries) is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension and some types of chronic heart failure. ACE raises blood pressure by constricting blood vessels. ACE inhibitors like enalapril prevent this effect. Enalapril has been shown to lower the death rate in systolic heart failure. Enalapril was the first member of the group of ACE inhibitors known as the dicarboxylate-containing ACE inhibitors.
Enalapril as a treatment for high blood pressure works by modulating the renin-angiotensin-aldosterone (RAS) system.
Squibb developed the first inhibitor, captopril, but it had adverse effects such as a metallic taste (which, as it turned out, was due to the sulfhydryl group). Merck & Co. developed enalapril as a competing prodrug.