Also Known As: Valtrex, Valaciclovir, Zelitrex, Valacyclovir

Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade names Valtrex and Zelitrex. As of November 25, 2009 (2009 -11-25), valacyclovir is marketed in generic form in the United States by Ranbaxy Laboratories.

Valaciclovir is indicated for the treatment of HSV and VZV infections, including:[9]

  • Oral and genital herpes simplex (treatment and prophylaxis)
  • Reduction of HSV transmission from people with recurrent infection to uninfected individuals
  • Herpes zoster (shingles): the typical dosage for treatment of herpes is 1,000mg orally three times a day for seven consecutive days. [10]
  • Prevention of CMV disease following organ transplantation
  • Prophylaxis against herpesviruses in immunocompromised patients (such as patients undergoing cancer chemotherapy)[11]

It has shown promise as a treatment for infectious mononucleosis,[3][4][5] and is preventively administered in suspected cases of herpes B virus exposure.[citation needed]

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