Also Known As: Pemoline, Cylert, Betanamin, Tradon

Pemoline was first synthesized in 1913 but its activity was not discovered until the 1930s. Under the names (Betanamin, Cylert, Tradon) it was used as a medication used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy. Under the Convention on Psychotropic Substances, it is a Schedule IV drug. It is no longer generally available in the United States. However, it can be legally prescribed in the US via the complex and rarely used "compassionate use / orphan drug" process by which a physician may complete extensive paper work on behalf of a single patient to obtain an "investigational new drug application" that allows importation and prescription of the compound on a case by case basis for up to one year and subject to renewal.

Unlike other psychostimulants which are dopaminergic, pemoline is thought to be dopamimetic in nature. Pemoline passes the blood brain barrier and acts a surrogate for dopamine, not effecting endogenous intracellular dopamine. For this reason, and the fact that it has little or no affinity for adrenaline receptors, pemoline has minimal sympathomimetic side effects such as: dry mouth, reduction in appetite, high blood pressure, increased heart rate, constriction of smooth muscle, cardiac stress, dilated pupils and insomnia. There is some data to suggest that pemoline is a nootropic acting as a catalyst conductor in the synapses of the brain's memory centers, raising the efficiency of memory and assisting RNA formation in the brain. While drugs like Adderall and Ritalin are classified as Schedule II, pemoline is listed as Schedule IV (non-narcotic.) In studies conducted on primates, pemoline fails to demonstrate a potential for self-administration.

Print this Page

All Treatments

Average Effectiveness

This is the Average effectiveness per ailment as reported by our participants (you).

  • 0 = No improvement or Worse
  • 1 = Slight improvement
  • 2 = Moderate Improvement
  • 3 = Significant Improvement
  • 4 = Cured

Order By

Type of Treatment

Date Range

Minimum Number of Users

Complete a survey on Pemoline to help the CureCrowd community

If you have tried to treat this ailment, please complete the following form to help us better our data, and help guide people to the best possible treatments. CureCrowd is a public resource with absolutely no vested interest in the outcomes of our studies.