Doxepin

Also Known As: Doxepin, Adapine, Doxal, Deptran, Sinquan, Sinequan

Doxepin is a psychotropic agent with tricyclic antidepressant and anxiolytic properties, known under many brand-names such as Aponal, the original preparation by Boehringer-Mannheim, now part of the Roche group; Adapine, Doxal (Orion), Deptran, Sinquan and Sinequan (Pfizer). As doxepin hydrochloride, it is the active ingredient in cream-based preparations (Zonalon and Xepin) for the treatment of dermatological itch. Doxepin is also used for the treatment of sleep maintenance, and the tradename of doxepin for this indication is Silenor.

Doxepin is used to treat depression, anxiety disorders, and as a second line treatment of chronic idiopathic urticaria.[1]

  • Insomnia[2]
  • low dose doxepin (3 to 6 mg) is an FDA approved use in the treatment of insomnia[3]
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