Also Known As: Zyrtec, Cetirizine, Reactine, Aller-tec

Cetirizine, a third-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.

Formerly prescription-only in the USA and Canada, cetirizine is now available over-the-counter in both countries as Zyrtec and Reactine respectively. Zyrtec was the highest-grossing new non-food product of 2008 in the US, generating sales of $315.9 million.[2] It is also available as a generic drug. In Australia and New Zealand, Zyrtec is available over-the-counter in pharmacies and in the UK cetirizine can be sold in limited quantities off-the-shelf in any outlet and is often available in supermarkets. As of 2009, Germany made many generic drugs containing cetirizine available in pharmacies without prescription.[3] Norway, Sweden[4], Finland, Poland and Israel also recognize Cetirizine as an over-the-counter medicine.

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