Also Known As: Zosyn, Piperacillin/tazobactam, Tazocin

Piperacillin/tazobactam is a combination antibiotic containing the extended-spectrum penicillin antibiotic piperacillin and the β-lactamaseinhibitor tazobactam. It is commercially available as e.g. Tazocin (Canada, UK, Australia and New Zealand, marketed by Pfizer) and Zosyn (U.S., by Pfizer). The combination has activity against many Gram-positive andGram-negative pathogens and anaerobes, including Pseudomonas aeruginosa.

Its main uses are in intensive care medicine (pneumoniaperitonitis), somediabetes-related foot infections, and empirical therapy in febrile neutropenia(e.g., after chemotherapy). The drug is administered intravenously every 6 or 8 hr, typically over 30 min. It may also be administered by continuous infusion over 4 hours. Prolonged infusions are thought to maximize the time serum concentrations are above the minimum inhibitory concentration (MIC) of the bacteria implicated in infection.

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