Also Known As: Pergonal, Menotropin, Human Menopausal Gonadotropin

Menotropin (also called human menopausal gonadotropin or HMG) is an active substance for the treatment of fertility disturbances. It consists of gonadotropins that are extracted from the urine of postmenopausal women, usually luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Often, it contains human chorionic gonadotropin (hCG) as well.

Menotropin medications include Menopur, Menogon, Repronex, Pergonal and HMG Massone. HMG (Human Menopausal Gonadotropin) is used for stimulating hormones by triggering FSH and LH production in the body. This drug was originally designed for use in women where it stimulates the ovaries to produce multiple follicles, thus making them more fertile.

Human urinary-derived menotropin preparations are exposed to the theoretical risk of infection from menopausal donors of urine. Nevertheless, the failure to demonstrate irrefutably infectivity following intracerebral inoculation with urine from TSE-infected hosts suggests that the risk associated with products derived from urine is merely theoretical.

The Practice Committee of the American Society for Reproductive Medicine reported: “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance. There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”

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