Percodan is a drug marketed by Endo Pharmaceuticals. It is a tablet containing a mixture of 325 mg (5 grains) of aspirin and 4.8355 mg of oxycodone HCl (equivalent to 4.3346 mg of oxycodone as the free base). It is used to treat moderate to severe pain. The safety of Percodan during pregnancy has not been established, although aspirin is generally contraindicated during pregnancy, and Percodan has been placed in pregnancy category D. Inactive ingredients include D&C Yellow 10, FD&C Yellow 6, microcrystalline cellulose, and corn starch. Percodan was first marketed by DuPont Pharmaceuticals and prescribed in the United States in 1950. At one time one of the most widely prescribed painkillers, Percodan has largely been replaced by alternative oxycodone compounds containing acetaminophen (Tylenol) instead of aspirin, such as Percocet.