Also Known As: Trimetrexate, Neutrexin

Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.

It has been used with leucovorin in treating pneumocystis pneumonia.[2]

It has been investigated for use in treating leiomyosarcoma.[3] It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. [4]

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