Fosfomycin

Also Known As: Fosfomycin, Monurol, Phosphomycin, Monuril

Fosfomycin (also known as phosphomycin and phosphonomycin) (trade names Monurol, Monuril) is a broad-spectrum antibiotic produced by certain Streptomyces species.

Fosfomycin is indicated in the treatment of urinary tract infections, where it is usually administered as a single oral megadose.[4] Its use in combination with tobramycin to treat lung infections in patients with cystic fibrosis was also explored.[5][6]

The drug is well tolerated and has a low incidence of harmful side-effects.[4] However, development of bacterial resistance under therapy is a frequent occurrence and makes fosfomycin unsuitable for sustained therapy of severe infections.

Additional uses have been proposed.[7] The global problem of advancing antimicrobial resistance has led to a renewed interest in its use more recently.[8]

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