Also Known As: Fosfomycin, Monurol, Phosphomycin, Monuril
Fosfomycin (also known as phosphomycin and phosphonomycin) (trade names Monurol, Monuril) is a broad-spectrum antibiotic produced by certain Streptomyces species.
Fosfomycin is indicated in the treatment of urinary tract infections, where it is usually administered as a single oral megadose. Its use in combination with tobramycin to treat lung infections in patients with cystic fibrosis was also explored.
The drug is well tolerated and has a low incidence of harmful side-effects. However, development of bacterial resistance under therapy is a frequent occurrence and makes fosfomycin unsuitable for sustained therapy of severe infections.
Additional uses have been proposed. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use more recently.