Also Known As: Methamphetamine, Desoxyn, Methamfetamine, Methylamphetamine, Desoxyephedrine

Methamphetamine (USAN), also known as methamfetamine (INN),N-methylamphetamine, methylamphetamine, and desoxyephedrine, is a psychostimulant of the phenethylamine and amphetamine class of psychoactive drugs. Methamphetamine increases alertness, concentration, energy, and in high doses, may induce euphoria, enhance self-esteem and increase libido. Methamphetamine has high potential for abuse and addiction, activating the psychological reward system by triggering a cascading release of dopamine in the brain. Methamphetamine is FDA approved for the treatment of ADHD and exogenous obesity. It is dispensed in the USA under the trademark name Desoxyn.

As a result of methamphetamine-induced neurotoxicity to dopaminergic neurons, chronic abuse may also lead to post acute withdrawals which persist beyond the withdrawal period for months, and even up to a year. A study performed on female Japanese prison inmates suffering from methamphetamine addiction showed 20% experienced a psychosis resembling schizophrenia which persisted for longer than six months post-methamphetamine use; this amphetamine psychosis could be resistant to traditional treatment. In addition to psychological harm, physical harm - primarily consisting of cardiovascular damage - may occur with chronic use or acute overdose.

Methamphetamine has been Food and Drug Administration (FDA) approved in treating ADHD and exogenous obesity in both adults and children.[5]Methamphetamine is a Schedule II drug in the United States and is sold under the trademark name Desoxyn.[5]Desoxyn may be prescribed off-label for the treatment of narcolepsy and treatment-resistant depression

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