Also Known As: Leuprorelin, Leuprolide, Leuprolide acetate, Lupron depot

Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl)

An LH-RH (GnRH) analog, leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis[1] or uterine fibroids), to treat precocious puberty,[2] and to control ovarian stimulation in In Vitro Fertilization (IVF). It is considered a possible treatment for paraphilias.[3]

Leuprolide has been tested as a treatment for reducing sexual urges in pedophiles and other cases of paraphilia.[4][5] High doses are sometimes used to chemically castrate sex offenders.[6]

Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer's disease.[7]

Leuprolide is also used to treat chronic adrenal disease in ferrets.[citation needed] It also used for treatment of steroid abuse.[citation needed]

Leuprolide, along with triptorelin and goserelin, are often used to delay puberty in transgender youth until they are old enough to begin hormone replacement therapy.[8] They are also sometimes used as superior alternatives to anti-androgens like spironolactone and cyproterone for suppressing testosterone production in trans women.

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