Dalcetrapib

Also Known As: Dalcetrapib, JTT-705

Dalcetrapib or JTT-705 is a CETP inhibitor which was being developed by Hoffmann–La Roche until May 2012.[1][2] The drug was aimed at raising the blood levels of "good cholesterol" (cholesterol carried in HDL particles, aka HDL-C).[3] Prevailing observations indicate that high HDL levels correlate with better overall cardiovascular health, though it remains unclear whether raising HDL levels consequently leads to an increase in cardiovascular health.[4]

A 24 week clinical trial showed that dalcetrapib did increase HDL-C levels, supporting the agent's desired effect.[5] Further, the dal-PLAQUE phase IIb trial found evidence of plaquereduction.[6] Plaque reduction is an anticipated observation following an increase in HDL.[citation needed]

As of 2010 five phase II trials had started and there was no evidence of the raised blood pressure seen with torcetrapib.[5]

dal-VESSEL phase IIb trial found no evidence of flow-mediated dilatation improvement. A 17% increase of Lp-PLA2 mass level was noted.[7] Lp-PLA2 is associated with coronary heart disease and stroke.[citation needed]

dal-OUTCOMES phase III trial passed its first interim review in July on 2011 and will continue as planned.[8]

Development was halted on May 7, 2012 “due to a lack of clinically meaningful efficacy.”[2]

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