Also Known As: Repaglinide, Prandin, GlucoNorm, Surepost, Repaglid
Repaglinide (Prandin in the U.S., GlucoNorm in Canada, Surepost in Japan,Repaglid in Egypt, NovoNorm elsewhere) is for the treatment of type II diabetes. It is supplied by Novo Nordisk. It is sold in Japan by Dainippon Sumitomo Pharma.
Repaglinide belongs to the meglitinide class of blood glucose-lowering drugs.
Repaglinide lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the beta cells. This depolarizes the beta cells, opening the cells' calcium channels, and the resulting calcium influx induces insulin secretion.