Dimethyl fumarate

Also Known As: Dimethyl fumarate, Fumaderm, Tecfidera

Dimethyl fumarate (DMF) is the methyl ester of fumaric acid. DMF was initially recognized as a very effective hypoxic cell radiosensitizer.[2] Later, DMF combined with three other fumaric acid esters (FAE) was licensed in Germany as oral therapy for psoriasis (trade name Fumaderm).[3] Other diseases, such as necrobiosis lipoidica,granuloma annulare, and sarcoidosis were also found to respond to treatment with DMF in case reports or small patient series.[4] Phase III clinical trials found that DMF (BG-12) successfully reduced relapse rate and increased time to progression of disability in multiple sclerosis (trade name Tecfidera).[5][6] DMF is thought to have immunomodulatory properties without significant immunosuppression.[7]

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