Also Known As: Ethionamide, Trecator-sc
Ethionamide (2-ethylthioisonicotinamide, Trecator SC) is an antibiotic used in the treatment of tuberculosis.
Ethionamide works to induce expression of EthA, a NAD derivative which is toxic to fungi. The resistance mechanism of this drug is through EthR, resistance is common. Therefore, EthR inhibitors are of great interest.
It has been proposed for use in combination with gatifloxacin.
The action may be through disruption of mycolic acid.