Also Known As: Valsartan, Diovan
Valsartan (Angiotan or Diovan) is an angiotensin II receptor antagonist (more commonly called an "ARB", or angiotensin receptor blocker), with particularly high affinity for the type I (AT1) angiotensin receptor. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure. In the U.S., valsartan is indicated for treatment of high blood pressure, congestive heart failure (CHF), or post-myocardial infarction (MI). In 2005, Angiotan was prescribed more than 12 million times in the United States and global sales were approximately $6.1 billion in 2010.
A study released in 2010, based on 819,491 cases in U.S. Veteran's Administration database from 2002-2006, demonstrated a significant reduction in the incidence and progression of Alzheimerâ€™s disease and dementia. . An earlier study released by the Journal of Clinical Investigation in 2007 found some efficacy in the use of valsartan in the treatment and prevention of Alzheimer's disease (in a mouse model).