Also Known As: Demeclocycline , Declomycin, Demeclocycline
Demeclocycline (marketed as Declomycin, Declostatin and Ledermycin) is a tetracycline antibiotic.
It is derived from a strain of Streptomyces aureofaciens.
Resistance is gradually becoming more common, and demeclocycline is now rarely used for infections.
It is widely used (though off-label in many countries) in the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) when fluid restriction alone has been ineffective.
The use in SIADH actually relies on a side effect; demeclocycline induces nephrogenic diabetes insipidus (dehydration due to the inability to concentrate urine). The use of demeclocycline in SIADH was first reported in 1975, and, in 1978, a larger study found it to be more effective and better tolerated than lithium carbonate, the only available treatment at the time. Demeclocycline has since been the drug of choice for treating SIADH, although it may be superseded by vasopressin receptor antagonists.