Dapsone (diamino-diphenyl sulfone) is a medication most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). It is also second-line treatment for prophylaxis (prevention) against Pneumocystis pneumonia (PCP) caused by Pneumocystis jiroveci (formerly P. carinii) in HIV patients in whom CD4 counts are below 200/mm3.
Dapsone is an odorless white to creamy-white crystalline powder with a slightly bitter taste, used in combination with pyrimethamine in the treatment of malaria. Dapsone is commercially available as a gel 5% topical acne medication and is used as an acne treatment for mild to moderate acne in teens and adults. To treat acne, Dapsone is marketed as Aczone by Allergan. Oral Dapsone may also be prescribed for acne conglobata and acne fulminans, if conventional treatments for extremely severe acne, such as isotretinoin and prednisone, fail to work. Dapsone can also successfully treat other rashes like dermatitis herpetiformis