Also Known As: Flexeril, Cyclobenzaprine

Cyclobenzaprine, also known by the brand name Flexeril is a muscle relaxant medication used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. It is the most well-studied drug for this application, and it also has been used off-label for fibromyalgia treatment.

After sustaining an injury, muscle spasms may occur to stabilize the affected body part and prevent further damage. They also generate pain. Cyclobenzaprine is FDA-approved to treat such muscle spasms associated with acute, painful musculoskeletal conditions.[3] It decreases pain in the first two weeks,[4][12] peaking in the first few days, but has no proven benefit after two weeks.[4][13] Since no benefit is proven beyond that, therapy should not be continued long-term.[14] It is not useful for spasticity due to neurologic conditions such as cerebral palsy.[14][15]

Cyclobenzaprine has also shown effectiveness in the treatment of fibromyalgia symptoms, with a report of 4.8 patients needing treatment for each (1) patient reporting pain reduction (but no change in fatigue or tender points).[16] Like other tricyclic antidepressants, it is also prescribed off-label as a sleep-aid.[

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