Also Known As: Claritin, Loratadine
Loratadine (INN) is a second-generation H1 histamine antagonist drug used to treat allergies. Structurally, it is closely related to tricyclic antidepressants, such as imipramine, and is distantly related to the atypical antipsychotic quetiapine.
Loratadine is marketed by Schering-Plough under several trade names (e.g., Claritin) and also by Shionogi in Japan. It is available as a generic drug and is marketed for its non-sedating properties. In a version named Claritin-D or Clarinase, it is combined with pseudoephedrine, a decongestant; this makes it useful for colds as well as allergies but adds potential side-effects of insomnia, anxiety, and nervousness.
Loratadine is indicated for the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticaria (hives), and other skin allergies. For allergic rhinitis (hay fever), loratadine is effective for both nasal and eye symptoms: sneezing, runny nose, itchy or burning eyes. Loratadine could be also used to treat mild to moderate pain from headaches.