Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine and works by blocking Histamine H1 receptors.

It is sold under the brand name Benadryl Allergy Relief in the U.K. by McNeil Laboratories, not to be confused with Benadryl Once a Day, which is cetirizine and is also sold by McNeil in the U.K. It is available as an over-the-counter medication in the UK.

In the U.S., acrivastine is the active ingredient in the Semprex-D brand. Semprex-D is also acrivastine-based, but contains a decongestant, pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals LLC.

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